Povidones are available in different molecular weights. The higher the molecular weight, the greater the viscosity and consequently the adhesive strength. The K-value denotes the intrinsic viscosity of the polymer related to the molecular weight, and is derived from the relative viscosity of the aqueous solution measured at 25°C. The direct correlation between the molecular weight and properties enables the appropriate grade to be used in each formulation in the appropriate concentration in order to achieve the optimum effect.
In order to provide formulators with flexibility in the choice of wet granulation binders with good adhesive strength and ease of handing, JRS PHARMA offers 2 grades of wet binders: VIVAPHARM® PVP K30 and VIVAPHARM® PVP K25.
Typical Dynamic Viscosity for 10% (g/ml) solutions in water at 20°C [mPa·S]
VIVAPHARM® PVP K25
24.0 – 27.0
3.5 – 5.5
VIVAPHARM® PVP K30
29.0 – 32.0
5.5 – 8.5
VIVAPHARM® PVP K30 and K25 are low viscosity wet binders with a good balance between adhesive strength and ease of handling. It is highly adhesive at low viscosity, thus offering the optimal balance between adhesive strength and ease of handling at 2-5% (VIVAPHARM® PVP K30) or 4-7% (VIVAPHARM® PVP K25).
VIVAPHARM® PVP K30 and K25 has excellent solubility in water and a range of organic solvents, and is supplied as a free flowing powder with spherical particle morphology.
This ensures rapid dispersibility and ultimate flexibility in the solvent of choice. Due to its non-ionic property, it does not bear any risk of interaction with ionic APIs.