Microcrystalline Cellulose Spheres

Chemically Inert Carrier

VIVAPUR® MCC Spheres consist purely of microcrystalline cellulose, making them extremely robust and chemically inert. They are, therefore, excellently suited as a carrier system. API-layered VIVAPUR® MCC Spheres can be filled into capsules and compacted into tablets.

They possess a tight particle size distribution, allowing for better control and higher batch-to-batch consistency of API release profiles. The particle size uniformity minimizes segregation risks during encapsulation or tableting, permitting greater API content uniformity. Additionally, it is possible to apply different APIs in various concentrations and combine the coated spheres in a single unit dose.

VIVAPUR® MCC Spheres are available in a wide range of particle sizes.

Benefits of Using VIVAPUR® MCC Spheres

  • Biologically inert
  • Insoluble in water
  • High degree of sphericity
  • Moisture and heat resistant
  • Adapted for coating and tableting
  • Size < 200 µm available
  • Microcrystalline Cellulose

    Ph. Eur., NF, JP, E 460 (i)



    Main Application



    VIVAPUR® MCC Spheres 100

    70 – 140

    100 – 200

    - Water insoluble carrier

    - For organic solvent free API coating

    - Small particle sizes available

    - High robustness

    VIVAPUR® MCC Spheres 200

    45 – 70

    200 – 355

    VIVAPUR® MCC Spheres 350

    35 – 45

    355 – 500

    VIVAPUR® MCC Spheres 500

    25 – 35

    500 – 710

    VIVAPUR® MCC Spheres 700

    18 – 25

    710 – 1000

    VIVAPUR® MCC Spheres 1000

    14 – 18

    1000 – 1400



    Brochure VIVAPUR® MCC Spheres

    Multiparticulate systems become have increasingly important in state-of-the-art formulation development. VIVAPUR MCC SPHERES® are particularly beneficial as a carrier for multiple-API dosage forms and controlled release formulations.

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