Probiotics, defined as “live microorganisms which when administered in adequate amounts confer a health benefit on the host,” indicate promising potential for the companion animals. Normally probiotics are filled into capsules or sachets; however, these dosage forms pose challenges for administration to animals. These factors make it worth considering direct compression of probiotics into tablets.
Probiotics are very sensitive to pressure and their survival rate depends on compaction force. Most preferred excipients for direct compression of probiotics must be able to deliver both robust tablet hardness and less friability under already low compaction forces. The goal of this study was to optimize the balance between tablet hardness and probiotic survival rate in the direct compression tableting process.