Blending Efficacy of PROSOLV^® SMCC with Caffeine by Near-Infrared Spec

PROSOLV® SMCC produced blends with better uniformity (as easured by NIRS) than the EMCOCEL® -CSD blends. Use of PROSOLV® SMCC promoted faster blend uniformity with a challenging active, allowing shorter processing times. Blends with PROSOLV® SMCC demonstrated increased tablet hardness and reduced ejection forces as compared to those with EMCOCEL® -CSD. Caffeine assay results, particularly the acceptance value, pointed to the PROSOLV® SMCC Turbula blend as producing the best overall blend, improving both content uniformity and content accuracy of the resulting tablets.