Matrix Effects on the Performance of Disintegrants

Recommendations for the selection of disintegrants are usually based on the solubility of the tablet matrix and the active ingredient.
Wicking disintegrants, such as croscarmellose sodium (CCS), are commonly recommended for soluble matrices. Wicking enables fast distribution of water throughout the tablet matrix, thus leading to rapid dissolution of the soluble matrix components. Sodium starch glycolate (SSG) and other swellingtype disintegrants are often selected for insoluble matrices. In this case, the swelling potential of the disintegrant is utilized to mechanically disrupt the structure of the tablet. Crospovidone (PVPP) is considered a universally suitable disintegrant, exhibiting a combination of the three mechanisms mentioned above.

Performance of Disintegrants
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