The Use of EMDEX® in a Lactose-free Reformulation of Cetirizine Tablets

Spray-dried lactose is widely used as filler and binder in the pharmaceutical industry, but many adults are not able to di­gest lactose. Therefore, it is indispensable to provide alternatives to lactose-containing drugs in order to make them suitable for lac­tose intolerant patients. EMDEX® is a promising substitute for spray-dried lactose as it has similar powder and tableting pro­perties. The aim of this study was to test a lactose-free refor­mu­lation of cetirizine tablets. EMDEX® was used suc­cessfully as a lactose substitute in cetirizine tablets resul­ting in comparable tablet properties in terms of crushing strength, disintegration time and dissolution profile. Furthermore, the EMDEX® formu­lation was characterized by an excellent powder flow and low ejection forces during the tableting process.

The Use of EMDEX in a Lactose-free Reformulation of Cetirizine Tablets – Click to download the Brochure

Privacy Policy

We Value Your Privacy

This website uses external tools and components to provide you the best experience on our website. You will find more detailed information in our privacy policy.