VIVAPUR® MCG

Microcrystalline Cellulose and Carboxymethylcellulose Sodium

VIVAPUR® MCG is a synergistic, co-processed composite consisting of microcrystalline cellulose (MCC) and sodium carboxymethylcellulose (Na-CMC). It is a unique suspending and emulsifying agent, which facilitates a wide range of liquid dosage forms. Due to its extraordinary stabilizing mechanism, VIVAPUR® MCG can be used with a broad variety of active pharmaceutical ingredients (APIs), offering the opportunity for new applications and line extensions for existing products.

VIVAPUR® MCG is a free flowing powder. After activation, MCG builds an opaque-white dispersion which masks insoluble particles, giving the suspension a homogenous appearance. The dispersed VIVAPUR® MCG is distinguished by an odorless and tasteless, smooth but not slimy mouth feel, and handles flavors well. Upon agitation, MCG dispersions show a time-dependent decrease in viscosity and become liquid. A complete, also time-dependent, regeneration of the viscosity takes place during a subsequent rest period. This thixotropic behavior allows:

  • Outstanding sprayability of nasal sprays
  • Effortless dosing through drenches and dispensers
  • Accurate dosage of oral suspensions
  • Hassle-free handling of activated gel
  • Ideal pumpability
  • Smooth and pleasant swallowing without problems
  • Excellent content uniformity

VIVAPUR® MCG is used as a suspending agent, emulsifier, and thickener for:

  • Oral suspensions
  • Veterinary drenches
  • Nasal sprays
  • Reconstitutable powders
  • Gels, creams, and lotions

Benefits:

  • Easy handling of dry powder
  • Heat stability
  • Compatibility with a wide range of ingredients
  • Stable over a wide pH range
  • Safe for us in animal health products, pediatric suspensions, and nutraceuticals

Microcrystalline Cellulose and Carboxymethylcellulose Sodium, Ph. Eur., NF, E 460 (i) & E 466, FCC

 

NaCMC (%)

Particle Size

Viscosity
(mPa.s)

Main Application

VIVAPUR® MCG 581 P

8.3 – 13.8

>250 µm (60 mesh):
max. 0.1%
>75 µm (200 mesh):
max. 35%

72 – 168
(1.2% solids)

For "ready-to-use" suspensions and emulsion prepared with high shear forces.

VIVAPUR® MCG 591 P

8.3 – 13.8

>250 µm (60 mesh):
max. 0.1%
>45 µm (325 mesh):
max. 45%

39 – 91
(1.2% solids)

VIVAPUR® MCG 611 P

11.3 – 18.8

>250 µm (60 mesh):
max. 0.1%
>45 µm (325 mesh):
max. 50%

50 – 118
(2.6% solids)

For reconstitutable dry suspensions.

VIVAPUR® MCG 811 P

11.3 – 18.8

>250 µm (60 mesh):
max. 3%

2400 – 5600
(2.6% solids)

Highly effective dispersible cellulose grade for a variety of suspensions, emulsions, and spray applications.

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