PROSOLV® SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD). A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation.
PROSOLV® SMCC is unique in that it imparts both optimum compaction and superior flow to formulations. It also exhibits both brittle fracture and plastic deformation characteristics, leading to superior binding properties. The production process of PROSOLV® SMCC leads to homogenous and much finer CSD particle size distribution. This results in a five-fold specific surface area increase, as well as in a 30-50% compaction increase compared to traditional MCC. The increased surface area enables superior flow and increased compaction and results in improved content uniformity and stability in the formulation.
When used for direct compression, PROSOLV® SMCC can replace granulations, while significantly reducing the number of required excipients and use levels. PROSOLV® SMCC formulations produce distinctive, uniform, and cost effective tablets.
PROSOLV® SMCC is available in a number of different grades.
Silicified Microcrystalline Cellulose, NF
Average Particle Size by Laser Diffraction (µm)
Bulk Density (g/mL)
PROSOLV® SMCC 50
0.25 – 0.37
Formulas in which optimal compaction and decent flow is required.
PROSOLV® SMCC 50 LD
0.20 – 0.30
Best in class binder.
PROSOLV® SMCC 90
0.25 – 0.37
Formulas in which a balance of flow and compaction is required.
PROSOLV® SMCC HD 90
0.38 – 0.50
Formulas in which optimal flow and consolidation is required. This grade shows the best disintegration times.
PROSOLV® SMCC 90 LM
0.27 – 0.39
Equivalent to quality of PROSOLV® SMCC 90, but with lower moisture content (< 3%)