Layer by Layer: The Fundamentals of Multi-Layer Tableting

Multi-layer tableting offers an inexpensive and straightforward solution for a variety of challenging formulations. Enabling multi-phasic release systems, combinations of incompatible APIs, and gastro-retentive tablets, this under-utilized method provides efficiency and cost-savings compared to more popular complex processes.

This executive summary compares multi-layer formulation options to traditional methods, providing a step-by-step guide to the multi-layer tableting process, and offering crucial tips to formulating and manufacturing robust multi-layer tablets. Learn how tooling considerations, excipient selection, layer design, and tamping force adjustment can impact overall tablet robustness, as well as layer-to-layer adhesion.