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Benefits of Using High-Functionality Excipients in a Continuous Process

Exipient Selection

In a continuous process, mono-functional excipients must be added through individual feeders, possibly resulting in multiple sources of variability. Alternatively, a single high-functionality co-processed excipient can accomplish the same task using only one feeder, thus enhancing finished product performance while keeping variability to a minimum. This webcast will cover how one high-functionality excipient can provide significant benefits over using traditional mono-functional excipients.

A Rational Approach to Excipient Selection

Exipient Selection

The main focus of this webinar is on IR tablets, though much is applicable to chewable tablets, orally disintegrating tablets, or capsules.

The Importance of Binder Selection and its Impact on Tableting Results in Roller Compaction

Roller Compaction

Roller compaction is the manufacturing method of choice when the physical characteristics of the active do not allow for direct compression and wet granulation causes stability issues due to moisture and heat. In order to achieve the desired granule properties, it is crucial to select binders with good intrinsic compaction properties and reproducible milling results that allow good flowability and high re-compactability during the final tableting step.

How to Successfully Combine Multiple APIs Into a Single Dose

Multiple APIs in a single Dose

Combining multiple APIs into a single dose can be as simple as a direct compression blend tableting process. However, it's not always that easy; not all APIs are compatible with one another and different release rates for different APIs may be desired. Maintaining these critical material attributes while achieving proper content uniformity, stability, and robust high speed processing can be challenging or even impossible.

Best Practices for Effective Tablet Lubrications

Best Practices for Effective Tablet Lubrications

Lubricants play a vital role in drug tableting applications; however, they can also produce disastrous results if not fully understood and used carefully. If the drug formulation is under-lubricated, the tablet may be difficult to eject from the die; all or parts of the tablet may stick to the die or punch face. Over-lubrication can affect tablet hardness, extend disintegration times, slow drug dissolution, or even prevent tablets from binding. 

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