Technical Information

  • Adjustment of Rheological Properties for Veterinary Suspensions

    Adjustment of Rheological Properties for Veterinary Suspensions
    Oral suspensions, or drenches, are a popular and common approach to overcoming the many obstacles of administering medicines to animals. Formulating solid dosage forms into suspensions enables line extensions of existing products for various animal species. Suspensions can be administered orally by drench guns or syringes, and can be mixed into feed or metered by dosing pumps into drinking water. The selection of a suitable stabilizer to adjust the required rheological properties is a major challenge in the development of suspensions. The goal of this study was to develop an oral suspension for animals with optimal stability, administration, and palatability.
  • Animal Health - Joint Health Tablets

    Animal Health - Joint Health Tablets
    Simplify the Manufacturing of Joint Health Tablets for Dogs: A Case Study with Green-Lipped Mussel Extract. With a prevalence of over 20%, osteoarthritis, or degenerative joint disease, is the most common form of joint disease in dogs. Green-lipped mussel (GLM) powder is widely used for prevention and treatment of osteoarthritis and may reduce, or even eliminate, the need for conventional medical therapy—NSAID’s in particular.
  • Compression of Probiotics for Companion Animals

    Compression of Probiotics for Companion Animals
    Probiotics, defined as “live microorganisms which when administered in adequate amounts confer a health benefit on the host,” indicate promising potential for the companion animals. Normally probiotics are filled into capsules or sachets; however, these dosage forms pose challenges for administration to animals. These factors make it worth considering direct compression of probiotics into tablets.
  • Direct Compression of Probiotic Tablets with PROSOLV® EASYtab Nutra

    Direct Compression of Probiotic Tablets with PROSOLV® EASYtab Nutra
    Although probiotics are mostly administered in the form of capsules, there are some advantages of tablets in terms of production effort, cost efficiency and stability of the probiotic bacteria. As probiotics are sensitive to high pressure and temperature, it is essential to select appropriate excipients for direct compression to ensure sufficient viability of the bacteria cells during production and storage. The aim of the study was to investigate the performance of high-functional excipients for direct compression of probiotic tablets.
  • Dispersible Cellulose Navigator

    Dispersible Cellulose Navigator
    VIVAPUR® MCG is used as a suspending agent, emulsifier, opacifier, and thickener for oral suspensions, veterinary drenches, sprays (nasal, oral, or topical), reconstitutable powders, creams, gels, and lotions. This Dispersible Cellulose Navigator details the various available grades of VIVAPUR® MCG and their applications.
  • Influence of Different Lubricants on Tableting Characteristics and Dissolution Behavior

    Influence of Different Lubricants on Tableting Characteristics and Dissolution Behavior
    Apart from their desired effect of reducing the ejection force and punch adhesion, lubricants also have a considerable influence on the tablet hardness, disintegration, and dissolution times due to their inherent hydrophobicity. This study aimed to investigate the influence of the lubricant molecular structure on the aforementioned characteristics.
  • Performance of MCC Spheres and Sugar Spheres in a Multi-particulate Omeprazole Formulation

    Performance of MCC Spheres and Sugar Spheres in a Multi-particulate Omeprazole Formulation
    Robust and inert, spherical carriers are a prerequisite for the manufacture of multi-particulate dosage forms. In this study, spheres composed of microcrystalline cellulose (VIVAPUR® MCC SPHERES) were compared with sugar spheres.
  • Specific Excipient Requirements in Continuous Tablet Manufacturing

    Specific Excipient Requirements in Continuous Tablet Manufacturing
    Continuous Manufacturing Technology continues to gain importance in pharmaceutical manufacturing. Although traditional processes like direct compression, roller compaction, or wet granulation are used within the continuous lines, the requirement for ingredients may differ from traditional batch processing. This whitepaper analyzes the various steps of a continuous process in the light of excipient properties.
  • The Effect of Silicification on the Roller Compaction Performance of Microcrystalline Cellulose

    The Effect of Silicification on the Roller Compaction Performance of Microcrystalline Cellulose
    Roller compaction, or dry granulation, is a manufacturing method for pharmaceutical and nutraceutical tablets that continues to gain importance. In order to achieve the desired granule properties, it is vital to use efficient binder-filler systems, which enable easy compaction, reproducible milling results, and high re-compactibility during the final tableting step. This study examines the effect of silicification on the roller compaction performance of microcrystalline cellulose.
  • The Use of EMDEX® in a Lactose-free Reformulation of Cetirizine Tablets

    The Use of EMDEX® in a Lactose-free Reformulation of Cetirizine Tablets
    Spray-dried lactose is widely used as filler and binder in the pharmaceutical industry, but many adults are not able to di­gest lactose. Therefore, it is indispensable to provide alternatives to lactose-containing drugs in order to make them suitable for lac­tose intolerant patients. EMDEX® is a promising substitute for spray-dried lactose as it has similar powder and tableting pro­perties. The aim of this study was to test a lactose-free refor­mu­lation of cetirizine tablets. EMDEX® was used suc­cessfully as a lactose substitute in cetirizine tablets resul­ting in comparable tablet properties in terms of crushing strength, disintegration time and dissolution profile. Furthermore, the EMDEX® formu­lation was characterized by an excellent powder flow and low ejection forces during the tableting process.
  • VIVAPUR® MCG: A Powerful Stabilizer for Nasal Sprays

    VIVAPUR® MCG: A Powerful Stabilizer for Nasal Sprays
    Dispersible cellulose is a multifunctional and commonly used stabilizer for nasal sprays. VIVAPUR® MCG forms a three-dimensional coherent network of insoluble cellulose fibrils. All particles are kept homogenously within the gelled network. During agitation in the delivery device, the fibrils arrange themselves in the direction of the movement. The network loosens up and the viscosity decreases.
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