Oral suspensions, or drenches, are a popular and common approach to overcoming the many obstacles of administering medicines to animals. Formulating solid dosage forms into suspensions enables line extensions of existing products for various animal species. Suspensions can be administered orally by drench guns or syringes, and can be mixed into feed or metered by dosing pumps into drinking water. The selection of a suitable stabilizer to adjust the required rheological properties is a major challenge in the development of suspensions. The goal of this study was to develop an oral suspension for animals with optimal stability, administration, and palatability.
Probiotics, defined as “live microorganisms which when administered in adequate amounts confer a health benefit on the host,” indicate promising potential for the companion animals. Normally probiotics are filled into capsules or sachets; however, these dosage forms pose challenges for administration to animals. These factors make it worth considering direct compression of probiotics into tablets.
VIVAPUR® MCG is used as a suspending agent, emulsifier, opacifier, and thickener for oral suspensions, veterinary drenches, sprays (nasal, oral, or topical), reconstitutable powders, creams, gels, and lotions. This Dispersible Cellulose Navigator details the various available grades of VIVAPUR® MCG and their applications.
Roller compaction, or dry granulation, is a manufacturing method for pharmaceutical and nutraceutical tablets that continues to gain importance. In order to achieve the desired granule properties, it is vital to use efficient binder-filler systems, which enable easy compaction, reproducible milling results, and high re-compactibility during the final tableting step. This study examines the effect of silicification on the roller compaction performance of microcrystalline cellulose.
Dispersible cellulose is a multifunctional and commonly used stabilizer for nasal sprays. VIVAPUR® MCG forms a three-dimensional coherent network of insoluble cellulose fibrils. All particles are kept homogenously within the gelled network. During agitation in the delivery device, the fibrils arrange themselves in the direction of the movement. The network loosens up and the viscosity decreases.